Real-time treatment guidelines: considerations during the Exserohilum rostratum outbreak in the United States.
نویسندگان
چکیده
Peter G. Pappas, Dimitrios P. Kontoyiannis, John R. Perfect, Tom M. Chiller Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA; Division of Internal Medicine, Unit 1460, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Division of Infectious Diseases, Duke University Medical Center, Duke Hospital, Durham, North Carolina, USA; Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases, CDC, Atlanta, Georgia, USA
منابع مشابه
Exserohilum infections: review of 48 cases before the 2012 United States outbreak.
Exserohilum species are soilborne fungi that have been uncommon causes of human disease. The ongoing outbreak in the United States warrants improved understanding of this pathogen. We systematically reviewed all cases of Exserohilum spp. infections published before the outbreak in 2012 in order to provide a better understanding of the organism and its wider spectrum of human disease. Cases of E...
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Exserohilum rostratum was the major cause of the multistate outbreak of fungal meningitis linked to contaminated injections of methylprednisolone acetate produced by the New England Compounding Center. Previously, we developed a fungal DNA extraction procedure and broad-range and E. rostratum-specific PCR assays and confirmed the presence of fungal DNA in 28% of the case patients. Here, we repo...
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In 2012 the medical community in the United States faced an unprecedented outbreak of fungal meningitis caused by Exserohilum rostratum associated with injections of contaminated lots of methyprednilsone acetate. Rapid response by public health authorities led to the identification of the cause of the outbreak and the epidemic quickly abated, even though new cases were still being reported many...
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With interest, we read the paper by Korem et al. describing a case of Exserohilum rostratum sinusitis from which serum galactomannan (GM) levels were elevated upon diagnosis (1). They further demonstrated that the extract of the E. rostratum clinical isolate yielded positive GM results comparable to those generated by Aspergillus fumigatus. The authors concluded that the GM testing, approved by...
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A recent large outbreak of fungal infections by Exserohilum rostratum from contaminated compounding solutions has highlighted the need to rapidly screen available pharmaceuticals that could be useful in therapy. The present study utilized two newly-developed high throughput assays to screen approved drugs and pharmaceutically active compounds for identification of potential antifungal agents. S...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 4 شماره
صفحات -
تاریخ انتشار 2013